Diabetes

It is believed that diabetes develops in those who consume a lot of sweets. In reality it is a much more complex pathology, which depends only in part on nutrition and can develop in any person.

Diabetes mellitus: definition of the disease

Diabetes mellitus (DM) is a group of diseases associated with metabolic disorders. People with diabetes cannot digest carbohydrates properly. As a result, their glucose (blood sugar) concentration increases significantly.

Glucose is a type of sugar that serves as the body's main source of energy.

Excess glucose has a toxic effect and destroys the walls of blood vessels, nerve fibers and internal organs.

Diabetes mellitus develops for various reasons. Some types of diseases are genetic in origin, while others are linked to lifestyle or environmental factors.

The name of the disease was given by the ancient Greeks. Translated from Greek, διαβαίνω means "to pass through, " which refers to the main symptom of diabetes mellitus, polyuria, or frequent urination. For this reason, a person continually loses fluids and strives to replenish them by drinking as much water as possible.

However, this is not always the case. Some forms of diabetes can develop asymptomatically for a long time or occur so mildly that a person does not even notice that something has gone wrong. And even with the typical course of the disease, many years often pass before excess blood glucose leads to the development of symptoms of the disease. Furthermore, all this time the person is in a state of hyperglycemia and at the time of diagnosis already has serious irreversible disorders of the kidneys, blood vessels, brain, peripheral nerves and retina.

The disease causes significant damage to the body. Without treatment, excess glucose can lead to deterioration of the function of the kidneys, heart and nerve cells. But such complications can be prevented. Modern doctors have sufficiently effective drugs and techniques for treating diabetes.

Prevalence

In 2019, diabetes was the direct cause of 1. 5 million deaths worldwide. Furthermore, in almost half of the cases the disease was fatal in people under the age of 70. The other half of the patients died from complications of the disease: kidney failure, heart and vascular damage.

Besides humans, animals also suffer from diabetes. For example, dogs and cats.

From 2000 to 2019, the diabetes mortality rate in developed countries increased by 3% and in low- and middle-income countries by 13%. At the same time, the probability of death from complications of the disease in people aged 30 to 70 has decreased by 22% worldwide. It is believed that this is due to improved diagnosis of diabetes and effective methods for early prevention of its complications.

Classification of diabetes

In our country we use the diabetes mellitus classification approved by the World Health Organization in 1999.

Type I diabetes mellitus

With this type of disease, a person's pancreas produces a small amount of the hormone insulin, which is needed to transport glucose into cells. As a result, glucose entering the blood cannot be completely absorbed by cells, it remains in the vessels, is transported to the tissues and gradually destroys them.

Depending on the cause of pancreatic dysfunction, type I diabetes is divided into two subtypes: immune-mediated and idiopathic.

Immune-mediated diabetes mellitusthe result of autoimmune destruction of pancreatic cells, due to which the immune system mistakenly attacks its own healthy tissue. Diabetes typically begins in childhood or adolescence, but can develop in people of all ages.

Immune-mediated diabetes is often associated with other autoimmune diseases, such as Graves' disease, Hashimoto's thyroiditis, Addison's disease, vitiligo, or pernicious anemia.

Type 1 diabetes mellitus most often develops in children and adolescents, although it can occur at any age.

Idiopathic diabetes mellitus.A rare variant of the disease. Such patients have no laboratory signs of autoimmune damage, but symptoms of absolute insulin deficiency are observed.

Type II diabetes mellitus

In this case, the pancreas produces enough insulin, but the cells are insensitive or resistant to it, so they cannot absorb glucose and it accumulates in the blood.

Depending on the main cause, type II diabetes mellitus is divided into type II diabetes mellitus with predominant insulin resistance and relative insulin deficiency and type II diabetes mellitus with predominant alteration of insulin secretion with or without insulin resistance.

Other specific types of diabetes

Other specific forms of the disease include pathologies with a pronounced genetic component, associated with infectious diseases or taking certain drugs, and others.

Genetic defects in pancreatic β-cell functionthose types of diseases in the development of which a defective gene is clearly established.

Genetic defects in insulin actionthe development of the pathology is associated with the peripheral action of insulin, which is disrupted due to mutations in the insulin receptor gene.

Diseases of the exocrine pancreas.For example, chronic pancreatitis and other inflammatory pathologies.

Endocrinopathiespathologies associated with excessive secretion of other hormones, such as acromegaly, Cushing's disease, hyperthyroidism.

Drug- or chemical-induced diabetes, can occur when taking hormonally active substances, α- and β-adrenergic agonists, psychoactive drugs, diuretics and chemotherapy.

Diabetes associated with infectious diseases.As a rule, the disease develops due to viral infections (pathogens: Coxsackie virus, rubella, Epstein Barr).

Unusual forms of immunologically mediated diabetes.For example, immobility and rigidity syndrome, systemic lupus erythematosus.

Other genetic syndromes, sometimes combined with diabetes.

Gestational diabetes mellitus

It appears for the first time during pregnancy and is characterized by a decrease in the sensitivity of cells to glucose. It is believed that the disease develops due to hormonal imbalance. After giving birth, the condition returns to normal or may develop into type II diabetes.

Causes of diabetes

Diabetes mellitus develops for various reasons, including genetic and autoimmune diseases, chronic pancreatic diseases and dietary habits.

Common Causes of Diabetes:

• a malfunction of the immune system, due to which it attacks pancreatic cells;
• genetic disorders that compromise the sensitivity of tissues to glucose, modify the functioning of the pancreas and reduce or completely interrupt the synthesis of insulin necessary for the absorption of glucose;
• viral infections Coxsackie viruses, rubella, Epstein Barr, retroviruses can penetrate the cells of the pancreas and destroy the organ;
• chronic diseases affecting the pancreas, cystic fibrosis, pancreatitis, hemochromatosis;
• endocrine diseases Cushing's syndrome, acromegaly;
• toxins (e. g. rodenticides, used to kill rodents, heavy metals, nitrates);
• eating habits Excess fats and simple carbohydrates in the diet can lead to obesity and decreased cell sensitivity to insulin;
• drugs, some hormonal drugs (especially glucocorticosteroids), some drugs for the treatment of diseases of the heart and nervous system, preparations of B vitamins (if consumed in excess).

Risk factors for diabetes

Depending on the type of diabetes, the risk factors for the disease differ.

Risk factors for type I diabetes:

• heredity: the probability of getting sick is greater if blood relatives have diabetes;
• Some viral infections (for example, rubella, infectious mononucleosis) can trigger an autoimmune reaction in the body, causing the immune system to attack pancreatic cells.

Excess weight does not cause type I diabetes, but it increases the risk of developing type II diabetes.

The most common risk factors for type II diabetes mellitus, which are not directly related to increased blood glucose levels: excess weight, sedentary lifestyle, pregnancy, etc.

During physical activity, glucose is actively broken down to produce energy; substances supplied with food, as well as the body's fat reserves, are used as a substrate. With obesity, the volume and, accordingly, the area of the membranes of fat and other cells containing lipid inclusions increases, the relative density of insulin receptors per unit area decreases, as a result, the cells become less sensitive to 'insulin and absorb glucose worsening.

Risk factors for type II diabetes mellitus:

• overweight and obesity;
• a sedentary lifestyle (without physical activity, glucose is broken down more slowly, so cells may become less sensitive to insulin);
• diabetes mellitus in blood relatives;
• age over 45;
• Prediabetes is a condition in which the blood glucose level remains at the upper limit of normal for a long time. Prediabetes is said to be present if analyzes show values between 5. 6 and 6. 9 mmol/l;
• diabetes mellitus during pregnancy (gestational diabetes);
• birth of a child weighing more than 4 kg;
• depression;
• cardiovascular disease;
• arterial hypertension (pressure above 140/90 mm Hg);
• elevated levels of high-density "bad" cholesterol (more than 0. 9 mmol/l) and triglycerides (more than 2. 82 mmol/l);
• polycystic ovary syndrome.

Symptoms of diabetes

Type I diabetes mellitus usually manifests itself with pronounced symptoms; other types of disease can develop unnoticed for a long time.

Common Symptoms of Diabetes:

• strong thirst;
• weakness;
• frequent urination;
• nocturnal enuresis in children who have never wet the bed before;
• sudden weight loss for no apparent reason;
• constant strong feeling of hunger;
• frequent urinary tract infections or fungal infections.

Separately, there are the so-called secondary symptoms of diabetes mellitus, which appear in the later stages of the disease and signal complications.

Secondary symptoms of diabetes:

• itchy skin;
• nausea;
• vomit;
• abdominal pain;
• dry mouth;
• muscle weakness;
• blurred vision;
• wounds that heal poorly;
• numbness in the fingers or toes;
• acanthosis nigricans darkening of the skin of the neck, armpits, elbows and knees;
• diabetic dermopathy pigmentary spots with atrophy and peeling of the skin, located on the folds of the lower extremities, often appear due to poor healing of leg wounds;
• Diabetic pemphigus vesicles on the lower limbs ranging in size from a few millimeters to several centimeters. It most often occurs in elderly patients with long-term diabetes;
• heachache;
• smell of acetone from the mouth.

Acanthosis nigricans, or darkening of the skin on the neck, knees, elbows and armpits, can be a sign of diabetes.

Complications of diabetes

Complications typically develop in patients with advanced diabetes mellitus and include retinopathy, nephropathy, and polyneuropathy.

Destruction of large vessels leads to atherosclerosis, myocardial infarction, stroke and encephalopathy.

Constant monitoring of blood sugar levels and taking drugs to lower their levels can prevent or delay irreversible complications of diabetes.

In addition, the regeneration of small vessels is disrupted. Because of this, wounds on the body do not heal well. So, even a small cut can turn into a deep, purulent ulcer.

Diabetic coma

Diabetic coma is a complication of diabetes associated with too high or, conversely, low blood sugar levels.

Depending on the concentration of glucose in the blood, diabetic coma is divided into two types: hypoglycemic (associated with a decrease in sugar levels) and hyperglycemic (caused by an increase in its level).

Hypoglycemic comait usually occurs in people with diabetes who are taking insulin.

The cause of such a coma is excess insulin, which prevents the body from increasing blood glucose levels to normal levels. This often happens when the insulin dose is incorrectly calculated or the diet is interrupted, in which the amount of insulin administered does not match the carbohydrate portion of the food consumed.

Precursors of hypoglycemic coma:

• trembling in the body,
• chills,
• dizziness,
• nervousness or anxiety
• severe hunger
• nausea,
• blurred vision,
• heart rhythm disorder.

The "Rule 15" to stop hypoglycemia in diabetes:

If your "sugar" level is low, you should eat 15 g of fast carbohydrates (drink juice, take a glucose tablet) and measure your blood sugar after 15 minutes. If his level is low, eat another 15 g of fast carbohydrates. Repeat these steps until the sugar reaches at least 3. 9 mmol/l.

In rare cases, low blood sugar can cause a person to faint. In such a situation, he needs an urgent injection of the hormone glucagon, which is performed by an ambulance worker.

Some people mistakenly believe that a person in a hypoglycemic coma needs to have a sweet liquid poured into their mouth. However, this is not the case and is fraught with asphyxia (suffocation).

Hyperglycemic comaaccompanied by an acute lack of insulin, which can be caused by severe stress or an insufficient dose of insulin after meals.

We speak of dangerous hyperglycemia if the blood glucose level exceeds 13. 9 mmol/L.

Symptoms of hyperglycemia:

• strong thirst
• frequent urination,
• extreme tiredness
• blurred vision,
• smell of acetone or fruity breath,
• nausea and vomit,
• abdominal pain,
• rapid breathing.

If such symptoms appear, you should sit down as soon as possible, ask others to call an ambulance or call an ambulance yourself.

Diagnosis of diabetes mellitus

If a person has symptoms of increased blood sugar concentration: constant thirst, frequent urination, general weakness, blurred vision, numbness in the limbs, you should consult a family doctor as soon as possible.

But most often, diabetes mellitus develops asymptomatically, so it is recommended that all people undergo a screening test once a year to detect the disease in the early stages and prevent the development of complications.

Which doctor should I contact if I suspect diabetes mellitus?

As a rule, people first turn to a general practitioner. If diabetes is suspected, he refers them to a specialized specialist who treats metabolic disorders, an endocrinologist.

During the consultation, the doctor will carry out a survey and examination, and to confirm the diagnosis and determine the severity of diabetes, he will prescribe laboratory and instrumental tests.

Inspection

If diabetes is suspected, the doctor will clarify the anamnesis: cases of the disease in blood relatives, chronic pathologies of the pancreas, lifestyle, recent infectious diseases.

There are no specific signs of diabetes that can be detected during the examination.

During the examination, the doctor will also evaluate the condition of the skin: with diabetes mellitus, dark areas of acanthosis nigricans may appear. Additionally, a specialist can perform a rapid glucose test. Exceeding normal values is a reason for a thorough examination.

Laboratory research methods

For diagnosis, a blood sugar test is prescribed. Its high level along with characteristic symptoms such as constant thirst, frequent urination, frequent infectious diseases is a clear sign of diabetes.

Blood glucose concentration is measured using one of the following tests: fasting and postprandial blood glucose tests, glycated hemoglobin (HbA1c) level, which reflects the average blood sugar level over the last 3 months.

An HbA1c level of no more than 6. 0% (42 mmol/l), a glucose level of no more than 5. 5 mmol/l is considered normal.

To make an accurate diagnosis, the study is performed at least twice on different days. If the results are ambiguous, a glucose tolerance test is performed, which helps identify reduced cellular sensitivity to glucose.

Additionally, your doctor may order additional tests to distinguish type 1 diabetes from type 2 diabetes: an autoantibody test and a urine ketone body test.

Antibodies are usually present in people with type I diabetes and in ketone bodies with type II diabetes.

To evaluate the sensitivity of cells to insulin, your doctor may prescribe a test to calculate the HOMA-IR index (homeostatic model assessment of insulin resistance), which takes into account the level of glucose and insulin in the blood.

If hereditary forms of diabetes are suspected, experts may recommend genetic testing to identify mutations associated with hereditary forms of diabetes mellitus and glucose intolerance.

Instrumental research methods

Instrumental tests help identify complications of diabetes: damage to the retina, damage to the heart, blood vessels, kidneys and nerve conduction disorders.

An ultrasound examination of the internal organs is prescribed to evaluate the condition of the kidneys and pancreas. Additionally, the doctor may give the patient an ECG to detect abnormalities in the heart.

To diagnose visual disturbances, you will need to see an eye doctor. During an ophthalmological examination, the doctor evaluates the condition of the retina and examines the cornea through a slit lamp or using an ophthalmoscope.

Diabetes treatment

There is no cure for diabetes. Therapy aims to maintain acceptable blood glucose levels and prevent complications of the disease.

People diagnosed with diabetes need to regularly measure their blood glucose levels, inject insulin for type 1 diabetes or take tablets for type 2 diabetes or inject insulin to control blood sugar levels.

To prevent complications of the disease, the doctor may recommend other medications. For example, medications to control blood pressure, thin the blood, and prevent cardiovascular disease, as well as medications that lower blood cholesterol.

Monitoring blood glucose levels

Classic glucometers and modern continuous monitoring systems are used to monitor blood glucose levels.

A blood glucose meter is a device with a thin needle. A person pricks their finger and drips blood onto a special test strip. The blood glucose meter shows the result immediately.

Monitoring systems are sensors installed on the shoulder, stomach or leg. These sensors constantly monitor blood glucose levels. Data from the device is automatically downloaded to a special monitor or to an application on the phone. Such devices can report blood sugar spikes, plot glucose curves over periods of time, send information to your doctor, and even make recommendations about emergency and routine measures and the need to change diabetes treatment tactics.

Wearing the monitoring system doesn't hurt; it is not felt on the body.

Diet for diabetes

There is no special diet for people with diabetes, but it is important for people with this diagnosis to count the amount of carbohydrates they eat each day and keep a food diary.

Carbohydrate counting

Carbohydrates have the greatest impact on blood sugar levels, so it is important that people with diabetes do not eliminate them, but count them.

Carbohydrate counting is the basis of the diet for people with diabetes who are on insulin therapy. To do this, use the universal parameter bread unit (XE).

1 XE corresponds to approximately 15 g of net carbohydrates or 20–25 g of bread and increases blood glucose levels by an average of 2. 77 mmol/l. To absorb such an amount of glucose requires an insulin dose of 1. 4 units.

The amount of carbohydrates in the diet of a person with type I diabetes on average should not exceed 17 units of bread per day.

The amount of carbohydrates a person with diabetes can normally tolerate varies from person to person and depends on weight, level of physical activity, daily calorie needs, and how the body metabolizes carbohydrates.

You can calculate the necessary amount of carbohydrates per day with a nutritionist or your doctor. After you convert the carbohydrates you eat into bread units, your doctor will help you determine how much insulin you need to absorb glucose. Over time, a person will learn to calculate it himself.

Additionally, there are other dietary recommendations for people with diabetes:

• limit the calorie intake of all overweight patients;
• reduce the fat content (mainly of animal origin) and sugars in foods to a minimum;
• consume carbohydrates mainly from vegetables, whole grains and dairy products;
• exclude or limit the consumption of alcoholic beverages (no more than 1 conventional unit for women and 2 conventional units for men per day).

Prediction and prevention of diabetes mellitus

Diabetes mellitus is a chronic disease that cannot be completely cured. But medications and healthier lifestyle changes help avoid complications and slow the progression of the disease.

Without treatment, the prognosis for diabetes mellitus is unfavorable: a person can die due to damage to the cardiovascular system.

Ways to prevent diabetes:

• regular physical activity;
• varied diet with sufficient fibre, proteins, fats and carbohydrates;
• healthy weight control;
• reduce alcohol consumption;
• give up alcohol and smoking.

Nutrition for the prevention of type II diabetes mellitus

An important part of preventing type II diabetes is a healthy and varied diet. For this purpose, the principle, or method, of the healthy plate was developed.

The Healthy Plate Method divides foods into five main groups: fruits and vegetables, slow-release carbohydrates, dairy, proteins and fats. You can combine these groups using a regular plate. Fruits and vegetables should make up a third or half. Slow carbohydrates a third or so. The remaining part is occupied by dairy products, slightly higher protein foods and a small part by fats.

Eat according to the principle of a healthy dish: half is fiber, ⅓ slow carbohydrates, the rest protein foods.

In addition, other important principles of healthy eating should be observed:

• drink according to thirst;
• eat less salt, no more than one teaspoon (5-6 g) per day;
• limit the consumption of trans fats (present in many prepared and processed fast food products, cakes and pastries);
• reduce the consumption of saturated fats (present in sweet pastries, fatty meats, sausages, butter and lard);
• eat less sugar, no more than 7 teaspoons (30 g) per day.